Delivery of Vitamins through the Intraoral Cavity with Toothpaste Using Penetration Enhancers

Dental health is rarely deemed a significant factor for a healthy life despite its considerable impact on the human body. Many presume that regular dental check-ups and daily toothbrushing are sufficient to prevent oral health diseases. However, consuming certain nutrients is also required to attain a healthy oral cavity. Nutrients necessary for preserving dental health, namely calcium, phosphorus, fluorine, and various vitamins, contribute to the development, maintenance, and repair of oral tissues. Nevertheless, it can be challenging to be conscious of taking such nutrients on a daily basis. In this study, aiming to abolish such inconveniences, vitamins essential for dental health were combined in a toothpaste formulation with penetration enhancers (PEs) to achieve intraoral delivery of the vitamins while toothbrushing. Multiple tests were performed to evaluate the characteristics of the intraoral vitamin-delivery toothpaste (IOVT), such as abrasiveness and antibacterial strength tests. The same tests were also conducted on three different commercial toothpaste to draw comparisons with the IOVT. Additionally, to verify the IOVT’s penetration capability, a mass transport study, and a transepithelial electric resistance (TEER) value test were conducted using nightcrawlers’ skin. The data collected demonstrated congruency between multiple characteristics of the IOVT and those of the commercial toothpaste. Our key finding was that the greater TEER values demonstrated the high plausibility of effective intraoral delivery of vitamins, assisted by PEs, as components of the IOVT.