A Rare Case Presentation of Chondromyxoid Fibroma Involving the Sphenoid Sinus

Chondromyxoid fibroma (CMF) is an uncommon benign tumor of chondroid, myxoid and fibrous tissues. It is a rare bone tumor found mainly in long bones, so its presence at the base of the skull is particularly rare. The presence of monoclonal gammopathy of minor significance (MGUS) prompted the consideration and investigation of a plasma cell disorder. We describe the diagnosis and treatment of a 47-year-old female patient with a large CMF originating from the sphenoid sinus. However, chondromyxoid fibroma was correctly diagnosed based on CT and MRI results and a biopsy.