Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome

Krzesiński, Paweł and Piechota, Wiesław and Piotrowicz, Katarzyna and Gielerak, Grzegorz and Woźniak-Kosek, Agnieszka (2019) Association of Estimated Insulin Resistance with N-Terminal B-Type Natriuretic Peptide Concentration in Men with Metabolic Syndrome. Cardiology Research and Practice, 2019. pp. 1-6. ISSN 2090-8016

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Abstract

Background. The diagnostic and prognostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure is well established. However, additional factors may influence its concentration. One of them is obesity, which in general is accompanied by reduced NT-proBNP levels. However, specific data concerning metabolic syndrome (MS) are equivocal. The aim of the present study was to evaluate the association of NT-proBNP with estimated insulin resistance (eIR) in men with MS. Methods. In 86 male patients with MS (78 of them hypertensive), blood pressure, anthropometric measures, NT-proBNP, creatinine, glucose, and insulin were assessed and eIR was calculated using homeostatic model assessment (HOMA-IR). Results. Both eIR and age were independently associated with NT-proBNP concentrations (b = 0.2248, ; b = 0.0102, , respectively). Blood pressure, anthropometric measures, and eGFR were not correlated with NT-proBNP. Patients without eIR had higher NT-proBNP than those with eIR (32.2 ± 26.4 vs 21.4 ± 25.4 pg/mL, ). The difference was even higher in the younger subgroup of patients reaching nearly 50%. Conclusions. Insulin resistance and, to a lesser degree, age were associated with NT-proBNP levels in men with MS. In younger subjects with eIR, mean NT-proBNP level was lower than in corresponding healthy age males.

Item Type: Article
Subjects: Opene Prints > Medical Science
Depositing User: Managing Editor
Date Deposited: 10 Feb 2023 07:16
Last Modified: 06 May 2024 06:22
URI: http://geographical.go2journals.com/id/eprint/934

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