Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease

Rajasekaran, Santhanasabapathy and Witt, Stephan N. (2021) Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease. PLOS Biology, 19 (7). e3001331. ISSN 1545-7885

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Official URL: https://doi.org/10.1371/journal.pbio.3001331

Abstract

In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes “infected” with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).

Item Type:	Article
Subjects:	Opene Prints > Biological Science
Depositing User:	Managing Editor
Date Deposited:	04 Mar 2023 07:34
Last Modified:	17 Jun 2024 06:04
URI:	http://geographical.go2journals.com/id/eprint/921

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