Histopathological study of prostatic lesions on needle biopsies with serum prostate-specific antigen (PSA)

Prostate develops from a series of endodermal buds from the lining of primitive urethra and the adjacent portion of urogenital sinus during the first 3 months of intra-uterine life. A prostate needle biopsy is a surgical procedure in which a small sample of tissue is removed from the prostate gland and examined under the microscope by a pathologist. In all investigated individuals, the level of prostate-specific antigen (PSA) was determined in identical way. PSA was estimated in venous blood by electro-chemiluminescence method. Histopathological analysis of obtained material was done on standard hematoxylin-eosin (H&E) preparations. Out of 60 patients studied, most of the patients 30 (50%) were diagnosed with benign prostatic hyperplasia (BHP). Higher levels of PSA (>20) was found in 57.1% of patients of BHP with chronic prostatitis table 11. Out of the total number of adenocarcinoma patients, 77.8% of the patients were having preoperative PSA levels greater than 20. In our study, the positive predictive value for increasing PSA levels was 8.3% for PSA <4 ng/ml, 16.6% for PSA >4 ng/ml, 24.2% for PSA >10 ng/ml and 83.3% for PSA >100 ng/ml.