Using Intradermal Rabies Vaccine to Boost Immunity in People with Low Rabies Antibody Levels

Brown, David and Fooks, Anthony R. and Schweiger, Martin (2011) Using Intradermal Rabies Vaccine to Boost Immunity in People with Low Rabies Antibody Levels. Advances in Preventive Medicine, 2011. pp. 1-5. ISSN 2090-3499

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Abstract

Intradermal rabies vaccine is recommended by the World Health Organisation, but not all countries, including England, follow this recommendation. A group of 12 adults in England previously given pre-exposure intradermal rabies vaccine were considered to be non-immune to rabies because their rabies antibody titres were known to be less than 0.5 IU/mL. A cohort study examined the immunizing effect of increasing the participants' cumulative dose of intradermal rabies to 2.0 IU. All patients subsequently demonstrated rabies antibody levels >0.5 IU·mL supporting evidence of adequate sero-conversion. No adverse effects of intradermal rabies vaccine boosting were noted. Within the limits of a small study the findings support the hypothesis that adequate levels of rabies antibody can be achieved by a schedule of intradermal injections delivered on at least three occasions with a cumulative rabies vaccine dose of 2.0 IU.

Item Type: Article
Subjects: Opene Prints > Medical Science
Depositing User: Managing Editor
Date Deposited: 11 Mar 2023 07:28
Last Modified: 17 Jun 2024 06:04
URI: http://geographical.go2journals.com/id/eprint/725

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