Clinicopathological characteristics and prognosis of gastrointestinal stromal tumors containing air-fluid levels

Liu, Tianzhu and Lin, Gao and Peng, Hui and Huang, Lesheng and Jiang, Xiaosong and Li, Hongyi and Cai, Kaili and Jiang, Jinghua and Guo, Lei and Du, Xiaohua and Tang, Jiahui and Zhang, Wanchun and Chen, Jun and Ye, Yongsong and Wellner, Ulrich (2021) Clinicopathological characteristics and prognosis of gastrointestinal stromal tumors containing air-fluid levels. PLOS ONE, 16 (12). e0261566. ISSN 1932-6203

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Abstract

An air-fluid level within a gastrointestinal stromal tumor (GIST) is unusual and indicates the presence of a fistula within the lumen of the GI tract. Until recently, the optimal management of such patients was not clear-cut. This retrospective study investigated the clinicopathological characteristics, surgical procedures, pre-and post-operative management, and prognosis of patients with GIST containing an air-fluid level. Data of GIST patients, spanning 5 years, including 17 GIST patients with air-fluid levels in the experimental group and 34 GIST patients without air-fluid levels in the control group, were retrieved from two hospitals in China. The clinicopathological characteristics, types of surgery, management, and clinical outcomes of GIST patients were compared between the two groups. GISTs containing air-fluid levels were significantly different from GISTs without air-fluid levels regarding tumor morphology, NIH risk category, invasion of adjacent organs, and necrosis or ulceration. Most GIST patients with air-fluid levels (14/17, 82.4%) received open surgery, significantly higher than the 20.6% in the control group. Targeted therapy with Imatinib mesylate (IM) was implemented in all GIST patients in the experimental group (17/17, 100%); markedly higher than those (3/34, 8.8%) in the control group. During follow-up, recurrence and death rates (5.9% and 5.9%) in the experimental group were higher than those (2.9% and 0%) in the control group. Open surgery is commonly performed in GIST patients with air-fluid levels who also require targeted therapy with IM. The Torricelli-Bernoulli sign could be a risk factor, adversely affecting the patient’s prognosis.

Item Type: Article
Subjects: Opene Prints > Biological Science
Depositing User: Managing Editor
Date Deposited: 26 Dec 2022 05:32
Last Modified: 15 Sep 2023 04:49
URI: http://geographical.go2journals.com/id/eprint/586

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