Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora

Teng, Haida and Li, Qingqing and Ma, Ziyu and Li, Xueni and Xie, Wenli and Chen, Yu and Yang, Guangzhong (2021) Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora. Frontiers in Chemistry, 9. ISSN 2296-2646

[thumbnail of pubmed-zip/versions/2/package-entries/fchem-09-756452-r1/fchem-09-756452.pdf]

Text
pubmed-zip/versions/2/package-entries/fchem-09-756452-r1/fchem-09-756452.pdf - Published Version
Download (1MB)

Official URL: https://doi.org/10.3389/fchem.2021.756452

Abstract

Eleven new polycyclic polyprenylated acylphloroglucinols (PPAPs, 1–11) and three new monocyclic polyprenylated acylphloroglucinols (MPAPs, 12–14), together with ten known analogues were isolated from the fruits of Garcinia multiflora. These PPAPs belong to three types including the bicyclic polyprenylated acylphloroglucinols (BPAPs), the caged PPAPs, and the complicated PPAPs. Their structures and absolute configurations were determined through HRESIMS, NMR spectroscopy data, electronic circular dichroism (ECD) calculations, and gauge-independent atomic orbital (GIAO) NMR calculations with DP4+ analyses. Moreover, compounds 2 and 7 exhibited moderate cytotoxicity against three human cancer lines (MCF-7, T98, and HepG2) with IC50 values ranging from 9.81 ± 1.56 to 17.00 ± 2.75 μM.

Item Type:	Article
Subjects:	Opene Prints > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	13 Feb 2023 09:53
Last Modified:	24 May 2024 05:34
URI:	http://geographical.go2journals.com/id/eprint/576

Actions (login required)

: View Item