Synthesis, Characterization of Some Novel Derivatives of Thiazolo[2,3-b]dihydropyrimidine Possessing 4-Pyrazolyl Moiety and Evaluation of Their Biological Activities

This study focuses on Synthesis, characterization of Some Novel Derivatives of Thiazolo[2,3-b]dihydropyrimidine Possessing 4-Pyrazolyl Moiety and evaluation of their biological activities. A series of new 2-arylidene-5-(5-chloro-3-methyl-1-N-phenyl-pyrazol-4-yl)-6-carbethoxy-7-methyl-5H-thiazolo[2,3-b]pyrimidin-3(1H)- ones have been synthesized by a three component (MCR) reaction involving 4-(5-chloro-3-methyl-1-N-phenyl- pyrazol-4-yl)-5-carbethoxy- 6-methyl-3,4-dihydropyrimidin-2(1H)-thione, monochloroacetyl chloride and aryl aldehydes. Thiazoles and their derivatives are also found to be associated with various biological activities such as antibacterial, antifungal and anti-inflammatory. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. The newly synthesized compounds were screened for their antibacterial and antifungal activities and have exhibited moderate to excellent growth inhibition of bacteria and fungi. From the yield and purity of compounds it can be concluded that by this one pot method such complex molecule can be synthesized simply in acidic medium. From the activities of series III it was found that the molecule possesses OH, Unsaturation and Florine group have comparably very good antibacterial and antifungal activity with reference to standard drugs.