Yuldasheva, Gulnara A. and Zhidomirov, Georgii M. and Ilin, Aleksandr I. (2020) Determination of Antitumor Activity of Molecular Iodine Complexes with Lithium Halogenides and Bioorganic Ligands when Applied in Combination with Doxorubicin. In: Recent Progress in Microbiology and Biotechnology Vol. 3. B P International, pp. 52-59. ISBN 978-93-90206-99-5
Full text not available from this repository.Abstract
The antitumor activity of anti-infective drugs containing iodine complex with bio-organic ligands and
potassium and lithium halides (LiCl (I)- I2-a-dextrin-peptide) has been experimentally studied.
It is shown that the combined action of the drug containing LiCl (I)- I2-a-dextrin-peptide complexes and
doxorubicin on the growth of Ehrlich ascites carcinoma (EAC) significantly enhanced the antitumor
activity of doxorubicin.
Using the quantum-chemical approach at the DFT/B3PW91/6-31G** and MP2/midi level it is shown
that the enhancement effect of antitumor activity of doxorubicin by molecular iodine complexes with
lithium halogenides and bio-organic ligands is caused by the formation of a structure in which the
nucleotide pair is interlocked with doxorubicin with staking interaction and bound by coordination with
LiCl (I)- a-I2-dextrin complexes.
In this structure LiCl (I)- a-I2-dextrin complexes increase the stacking interaction of doxorubicin with
the nucleotide pair and become the inhibition center for the amino acid residue of arginine which is
part of the active site of topo I.
| Item Type: | Book Section |
|---|---|
| Subjects: | Opene Prints > Biological Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 09 Nov 2023 05:56 |
| Last Modified: | 09 Nov 2023 05:56 |
| URI: | http://geographical.go2journals.com/id/eprint/3029 |
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