Bio-applications of Bacterial Cellulose and Type I Collagen Conjugated with Resveratrol for Epithelial Defect Regeneration

Excellent wound dressing is essential for effective wound repair and regeneration. This chapter aims to evaluate the effectiveness of bacterial cellulose (BC) and type I collagen (COL) scaffolds conjugated with resveratrol (RSV) for wound management. BC and COL are biodegradable and renewable attractive polymers for medical applications which has a strong affinity for materials containing hydroxyl groups, meanwhile RSV has a 4'-hydroxyl group and exhibits good biocompatibility and no cytotoxicity. The results demonstrated that RSV was effectively released from the BC and COL scaffolds in vitro, and immunofluorescence staining showed that both scaffolds were highly biocompatible and regenerated epithelia. Additionally, Masson’s trichrome staining showed that the both scaffolds preserved the normal collagen-bundling pattern and induced re-epithelialization in defective rat epidermis. These results indicate that RSV-conjugated BC or COL scaffold created a biocompatible environment for stem cell attachment and growth and promoted epithelial regeneration during wound healing.