Unpreventable Causes of Obesity: Genetic Factors and Susceptibility

India is currently going through a rapid health shift, with increase in rise of chronic diseases such as type 2 diabetes mellitus, hypertension, cardiovascular diseases, sleep disorders, liver diseases, arthritis, depression, cancer and many more. Obesity is among one of the leading factors for the development of these diseases. Obesity is on rising trend among all ages and racial groups, especially due to physical inactivity and increased energy intake in excess of energy expenditure, leading to accumulation of body fat that can be prevented. Other modifiable risk factors as socioeconomic status, sleep and many others also account for obesity and obesity-related diseases but these factors however, are not the only determinants of obesity. Besides modifiable risk factors, there are some un-modifiable risk factors also such as age, sex, genetics, ethnicity, gestational weight and other molecular factors that may be responsible to some extent. With the global increase in prevalence of obesity and obesity related diseases, it becomes important to have knowledge about the less known causes of obesity so as to decrease its rising trend so that we can implement appropriate and better preventive and interventional strategies.