The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India

Ralte, Vanlalruati S. C. and Loganathan, Archana and Manohar, Prasanth and Sailo, Christine Vanlalbiakdiki and Sanga, Zothan and Ralte, Lalremruata and Zothanzama, John and Leptihn, Sebastian and Nachimuthu, Ramesh and Kumar, Nachimuthu Senthil (2022) The Emergence of Carbapenem-Resistant Gram-Negative Bacteria in Mizoram, Northeast India. Microbiology Research, 13 (3). pp. 342-349. ISSN 2036-7481

[thumbnail of microbiolres-13-00027.pdf] Text
microbiolres-13-00027.pdf - Published Version

Download (541kB)

Abstract

(Background) Numerous reports on carbapenem resistance in different parts of India have been published, yet there are insufficient studies on the prevalence of antibiotic resistance in the northeast region of the country. This study evaluated the emergence of carbapenem resistance in the clinical isolates collected in Mizoram. (Results) A total of 141 Gram-negative clinical isolates were collected from the two hospitals, including the Civil Hospital in Lunglei and the Synod Hospital in Aizawl. The isolates include Escherichia coli (n = 62, 43.9%), Klebsiella spp. (n = 43, 30.4%), Pseudomonas aeruginosa (n = 9, 6.3%), Serratia marcescens (n = 3, 2.1%), Proteus mirabilis (n = 2, 1.4%), Shigella spp. (n = 4, 2.8%), Enterobacter spp. (n = 6, 4.2%) and Acinetobacter spp. (n = 12, 8.5%). The isolates were found to be resistant to meropenem (11%), colistin (48%), tigecycline (25%) and cefotaxime (50%). A total of four E. coli and one Shigella sonnei encoded the blaOXA-48-like gene. The blaCTX-M-1 gene was detected in 13 isolates, of which eight were E. coli, two Shigella flexneri, and one isolates each of K. pneumoniae, K. oxytoca and Shigella sonnei, respectively. (Conclusion) Carbapenem-resistant Enterobacteriaceae are common among other parts of India, despite limited access to antibiotics, the emergence of resistance in the northeastern region is worrying.

Item Type: Article
Subjects: Opene Prints > Medical Science
Depositing User: Managing Editor
Date Deposited: 15 Jun 2023 04:54
Last Modified: 30 Oct 2023 04:46
URI: http://geographical.go2journals.com/id/eprint/2173

Actions (login required)

View Item
View Item