Association between Raised Serum Lactate Dehydrogenase and Hypertensive Disorders of Pregnancy

Objective: To determine the association between raised serum lactate dehydrogenase (LDH) and hypertensive disorders of pregnancy.

Material and Methods: This case control study was conducted in the department of Obstetrics and Gynecology, at Liaquat University of Medical and health Sciences Jamshoro, Hyderabad, for a period of six months from July 2021 to December 2021. All the pregnancy hypertensive disorder women as cases and normotensive women as control of ages between 18 and 45 years with gestational age >28 weeks, irrespective of parity and booking stratus were included. Under aseptic conditions, from each woman of both groups around a 2 ml venous blood sample was taken (before treatment) for the assessment of serum LDH levels. Serum LDH levels more than 280 U/L was considered as raised. All the informations were noted on predesigned proforma by the researcher herself. SPSS version 26 was used for the data analysis.

Results: A total of 100 cases were included, particularly 50 women having hypertensive disorders of pregnancy and 50 normotensive pregnant women were studied. The overall mean age of the female’s was 25.76+5.39 years and average BMI was 32.7+2.02 kg/m2. Out of all 65.0% were primiparous. Most of the females 76.0% were poor socioeconomically. LDH was raised among 62.0% of the women with hypertensive disorders of pregnancy and it was normal among all normotensive pregnant women. Average serum LDH level was significantly higher in cases as compared to the controls (0.001).

Conclusion: Raised serum lactate dehydrogenase (LDH) was observed to be significantly linked to hypertensive disorders of pregnancy. Careful monitoring of serum LDH concentrations during pregnancy in high-risk cases may play a role in early detection and treatment to decrease the morbidity and mortality.