Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents

Barresi, Elisabetta and Baglini, Emma and Poggetti, Valeria and Castagnoli, Jacopo and Giorgini, Doralice and Salerno, Silvia and Taliani, Sabrina and Da Settimo, Federico (2024) Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents. Molecules, 29 (9). p. 2127. ISSN 1420-3049

[thumbnail of molecules-29-02127.pdf] Text
molecules-29-02127.pdf - Published Version

Download (23MB)


Neurodegeneration is a gradual decay process leading to the depletion of neurons in both the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions and the deterioration of brain functions, alongside a decline in motor skills and behavioral capabilities. Neurodegenerative disorders (NDs) impose a substantial socio-economic strain on society, aggravated by the advancing age of the world population and the absence of effective remedies, predicting a negative future. In this context, the urgency of discovering viable therapies is critical and, despite significant efforts by medicinal chemists in developing potential drug candidates and exploring various small molecules as therapeutics, regrettably, a truly effective treatment is yet to be found. Nitrogen heterocyclic compounds, and particularly those containing the indole nucleus, which has emerged as privileged scaffold, have attracted particular attention for a variety of pharmacological applications. This review analyzes the rational design strategy adopted by different research groups for the development of anti-neurodegenerative indole-based compounds which have the potential to modulate various molecular targets involved in NDs, with reference to the most recent advances between 2018 and 2023.

Item Type: Article
Subjects: Opene Prints > Multidisciplinary
Depositing User: Managing Editor
Date Deposited: 10 May 2024 07:39
Last Modified: 10 May 2024 07:39

Actions (login required)

View Item
View Item