Ciclosporin Eye Drops in Ocular Graft-Versus-Host Disease: A Case Report

Mehdi, EL Filali EL and Benelkadri, Farah and Lhaj, Houssaine Ait and Kriet, Mohamed and Asri, Fouad EL (2024) Ciclosporin Eye Drops in Ocular Graft-Versus-Host Disease: A Case Report. Asian Journal of Research and Reports in Ophthalmology, 7 (1). pp. 102-106.

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Aims: To report a case of severe ocular graft-versus-host disease (GVHD) managed with topical ciclosporin.

Introduction: Ocular graft-versus host disease is a rare and often misdiagnosed aetiology of dry eye syndrome.

Case: We report a case of young women presenting with a severe and bilateral ocular surface inflammation with filamentous keratitis, posterior blepharitis, Meibomian gland dysfunction and neovascular invasion. Ocular GVHD was diagnosed due to severe dry eye symptoms and a history of allogeneic haematopoietic stem cell transplantation. Immunosuppressive treatment resulted in a spectacular anatomical and clinical improvement, rapid resolution of symptoms and improvement in visual acuity.

Conclusion: Ocular GVHD should be considered in any severe dry eye syndrome associated with allogeneic bone marrow transplantation. Topical immunosuppressive therapies have revolutionised the curative management of these patients.

Item Type: Article
Subjects: Opene Prints > Medical Science
Depositing User: Managing Editor
Date Deposited: 30 Apr 2024 11:22
Last Modified: 30 Apr 2024 11:22

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