A Detailed Review on Effects of Metosartan on Testes Tissue

Metosartan induces so many deleterious effects in male Wistar rats treated with drug and RNase. It
causes pre maturation of sperms and reduces the sperm count as well as reduces viable sperm
count. It mainly consists of two components metoprolol succinate and telmisartan which induces ds
breaks in DNA. It induces the x-chromosome desynapsis leading to testicular carcinoma. The effects
are so profound in case of drug than compared to the enzyme RNase. Metosartan induces apoptosis
in testicular tissue mainly through intrinsic pathway which is mainly due to genotoxic agents. The drug
mainly inhibits RNase A in rat testes and has positive effect on Mitosis. Release of Cyt C was high in
both testes and sperm of rat mitochondria compared to normal rats and its release causes activation
of intrinsic pathway of apoptosis by activating caspase 9 and formation of apoptosome complex which
finally leads to death of the tissue. So, in-vivo analysis has shown drug treatment results in apoptosis
in both testes tissue and sperm cells.